Large B-Cell Lymphoma Prognosis
Studies from Gyeongsang National University, Department of Internal Medicine yield new data on large B-cell lymphoma prognosis
Published in Blood Weekly, January 7th, 2010
Investigators publish new data in the report 'Is inactivation of O6-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy.' "The prognostic significance of O6-methylguanine DNA methyltransferase (MGMT) inactivation was evaluated in patients with diffuse large B-cell lymphoma (DLBCL) who received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in addition to rituximab. In this retrospective study, we used the methylation-specific polymerase chain reaction to investigate MGMT promoter methylation status and immunohistochemistry to evaluate MGMT expression in patients with...
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Source: Blood Weekly (2010-01-07)
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