Mantle Cell Lymphoma

Studies from Northwestern University, Department of Pathology provide new data on mantle cell lymphoma

Published in Blood Weekly, January 21st, 2010

A new study, 'Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms,' is now available. According to a study from the United States, "Sox11 is a transcription factor involved in embryonic neurogenesis and tissue remodeling. Its role in lymphopoiesis is presently unknown."

"Recent studies have shown the nuclear expression of sox11 in mantle cell lymphoma, which raises the question about its possible association with t(11;14)(q13;q32), the genetic hallmark of mantle cell lymphoma leading to the overexpression of cyclin D1. In this study, we examined sox11 expression in 211...

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Source: Blood Weekly (2010-01-21)

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