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Gene Therapy

Study findings from University of Michigan broaden understanding of gene therapy

Published in Blood Weekly, January 28th, 2010

"Integrating inductivity with conductivity in a material may advance tissue engineering. An organic/inorganic hybrid was developed by incorporating plasmid DNA encoding for the beta-gal gene complexed with Lipofectamine 2000 ® (DNA-Lipoplex) within apatite via coprecipitation," scientists writing in the journal Biomaterials report.

"It was hypothesized that this system will result in enhanced transfection efficiency compared to DNA-Lipoplexes adsorbed to the mineral surface and DNA coprecipitated without Lipofectamine 2000 ®. PLGA films were cast onto glass slips and apatite and DNA were coprecipitated in modified simulated body fluid (mSBF)....

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