Life Sciences
New research on life sciences from Hokkaido University summarized
Published in Blood Weekly, February 11th, 2010
New research, 'The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal,' is the subject of a report. According to a study from Sapporo, Japan, "Spectrin strengthens the red cell membrane through its direct association with membrane lipids and through protein-protein interactions. Spectrin loss reduces the membrane stability and results in various types of hereditary spherocytosis."
"However, less is known about acquired spectrin damage. Here, we showed that alpha-and beta-spectrin in human red cells are the primary targets of the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) by immunoblotting and mass...
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Source: Blood Weekly (2010-02-11)
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