Large B-Cell Lymphoma

New data from S. Nagel et al illuminate research in large B-cell lymphoma

Published in Blood Weekly, February 25th, 2010

"Expression of CD44 variant (v) isoforms substantiates poor prognosis in patients with hematological malignancies. We have previously shown that CD44v6 expression in diffuse large B-cell lymphoma (DLBCL) correlates with advanced disease stage and is predominantly detected in non - germinal center B-cell - like DLBCL subtypes," investigators in Basel, Switzerland report.

"With the growing number of associated molecules found to form functional complexes with CD44, we analyzed a larger cohort of cyclophosphamide, doxorubicin, vincristine, prednisone, and equivalently treated DLBCL patients to define the prognostic role of such CD44-associated molecules. Two-hundred and...

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Source: Blood Weekly (2010-02-25)

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