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Wellcome Trust

Patients 'unafraid' to gamble highlight role of amygdala in decision-making

Published in Blood Weekly, February 25th, 2010

Two patients with rare lesions to the brain have provided direct of evidence of how we make decisions - and what makes us dislike the thought of losing money.

Researchers at the California Institute of Technology studied a phenomenon known as 'loss aversion' in two patients with lesions to the amygdala, a region deep within the brain involved in emotions and decision-making. The results of the study, part-funded by the Wellcome Trust, are published in the journal Proceedings of the National Academy of Sciences.

Loss aversion describes the avoidance of choices which can lead to losses, even when accompanied by equal or much larger gains. Examples in...

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