Life Sciences
Reports outline life sciences research from Sungkyunkwan University, Samsung Biomedical Research Institute
Published in Blood Weekly, March 11th, 2010
Research findings, 'Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate,' are discussed in a new report. According to a study from South Korea, "Ubiquitously expressed Mg(2+)-inhibitory cation (MIC) channels are permeable to Ca2+ and Mg2+ and are essential for cell viability. When membrane cholesterol level was increased by pre-incubating cells with a water-soluble form of cholesterol, the endogenous MIC current in HEK293 cells was negatively regulated."
"The application of phosphatidylinositol 4,5-bisphosphate (PIP2) recovered MIC current from cholesterol effect. As PIP2 is the direct modulator for MIC channels, high...
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Source: Blood Weekly (2010-03-11)
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