Bone Marrow Transplants
New bone marrow transplants research from Stanford University described
Published in Blood Weekly, March 11th, 2010
According to recent research published in the American Journal of Transplantation, "The goal of the study was to determine how the changed balance of host naive and regulatory T cells observed after conditioning with total lymphoid irradiation (TLI) and antithymocyte serum (ATS) promotes tolerance to combined organ and bone marrow transplants. Although previous studies showed that tolerance was dependent on host natural killer T (NKT) cells, this study shows that there is an additional dependence on host CD4(+)CD25(+) Treg cells."
"Depletion of the latter cells before conditioning resulted in rapid rejection of bone marrow and organ allografts. The balance of...
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Source: Blood Weekly (2010-03-11)
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