Cardiomegaly

Scientists at Zhejiang University publish new data on cardiomegaly

Published in Blood Weekly, March 11th, 2010

"Farnesyl pyrophosphate synthase (FPPS), an essential enzyme in the mevalonate pathway, was reported to be upregulated in young spontaneously hypertensive rats (SHR) when compared with Wistar-Kyoto (WKY) rats, and this was accompanied by development of left ventricular hypertrophy," scientists writing in the journal Biochemical Pharmacology report.

"Five-week-old rats were daily gavaged with vehicle or an FPPS inhibitor (alendronate, I or 10 mg/kg) and blood pressures was monitored by the tail-cuff method every other week. Twelve weeks of alendronate treatment attenuated the left ventricular weight to body weight ratio (LVW/BW), hydroxyproline content, collagen...

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Source: Blood Weekly (2010-03-11)

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