Tissue Engineering

Study data from Waseda University update understanding of tissue engineering

Published in Blood Weekly, April 8th, 2010

"Coordinated recovery of hepatic glucose metabolism is prerequisite for normal liver regeneration. To examine roles of hypoxia inducible factor-1 alpha (HIF-1 alpha) for hepatic glucose homeostasis during the reparative process, we inactivated the gene in hepatocytes in vivo," scientists writing in the journal Biochemical and Biophysical Research Communications report.

"Following partial hepatectomy (PH), recovery of residual liver weight was initially retarded in the mutant mice by down-regulation of hepatocyte proliferation, but occurred comparably between the mutant and control mice at 72 h after PH. At this time point, the mutant mice showed lowered blood...

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Source: Blood Weekly (2010-04-08)

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