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Children's Hospital Boston

Targeting Cell Pathway May Prevent Relapse of Leukemia

Published in Blood Weekly, April 8th, 2010

About 40 percent of children and up to 70 percent of adults in remission from acute myelogenous leukemia (AML) will have a relapse. In recent years, doctors have come to believe that this is due to leukemia stem cells, endlessly replicating cancer cells that generate the immature blood cells characteristic of leukemia and are resistant to typical cancer treatments. Now, researchers at Children's Hospital Boston have found a possible way to kill off these cells, and prevent them from initiating a relapse.

The study, published online March 26 in the journal Science, shows that leukemia stem cells cannot thrive without a particular cell pathway, known as the...

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