Chronic Lymphocytic Leukemia

Research from Medical University of Vienna in chronic lymphocytic leukemia provides new insights

Published in Blood Weekly, April 15th, 2010

According to recent research from Vienna, Austria, "One characteristic of chronic lymphocytic leukaemia (CLL) lymphocytes is high expression of CD23, which has previously been identified as a downstream target for NOTCH2 signalling. The mechanisms regulating NOTCH2-dependent CD23 expression, however, are largely unknown."

"This study showed that peripheral CLL cells overexpressed transcriptionally active NOTCH2 (N2IC), irrespective of their prognostic marker profile. When placed in culture, NOTCH2 activity was spontaneously decreased in 25 out of 31 CLL cases (81%) within 24 h. DNA-bound N2IC complexes could be maintained by the protein kinase C (PKC) activator phorbol...

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Source: Blood Weekly (2010-04-15)

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