Published in Blood Weekly, April 15th, 2010
"This study showed that peripheral CLL cells overexpressed transcriptionally active NOTCH2 (N2IC), irrespective of their prognostic marker profile. When placed in culture, NOTCH2 activity was spontaneously decreased in 25 out of 31 CLL cases (81%) within 24 h. DNA-bound N2IC complexes could be maintained by the protein kinase C (PKC) activator phorbol...
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