Polyomavirus

Research on polyomavirus discussed by scientists at University of Basel

Published in Blood Weekly, April 15th, 2010

"Polyomavirus (PV) associated nephropathy (PVAN) has become an important cause of allograft dysfunction. We studied plasma cells (PCs) - which have not yet been characterized - present in the cellular infiltrate of 20 PVAN cases using immunohistochemistry and morphometry," scientists in Basel, Switzerland report.

"The results were correlated with morphological, clinical and anti-BK virus serological findings. PC-rich cellular infiltrates occurred in 50% of cases (> 15% PCs in the cellular infiltrate) and in these IgM producing PCs were commonly seen (70%): IgM PC predominance in 50% of cases and a comparable number of IgM and IgG PCs in 20% of cases. We found a...

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Source: Blood Weekly (2010-04-15)

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