Immunization

New immunization study findings recently were published by researchers at Innsbruck Medical University

Published in Blood Weekly, April 22nd, 2010

According to a study from Innsbruck, Austria, "The efficiency of immunotherapy using tumor-antigen-loaded dendritic cells (DCs) is severely limited by the impaired migration of injected cells from the application site to the draining lymph nodes. As described earlier, pretreatment of the injection site with inflammatory cytokines enhances DC migration."

"We wanted to test whether toll-like receptor (TLR) ligands can improve migration of murine bone marrow-derived DC (BMDC) and the subsequent T-cell responses. For this purpose, we established an experimental setup closely resembling human vaccination protocols that served to investigate DC migration from the skin to the...

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Source: Blood Weekly (2010-04-22)

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