Small Lymphocytic Lymphoma

Research data from C. Rabascio and colleagues update understanding of small lymphocytic lymphoma

Published in Blood Weekly, April 22nd, 2010

According to a study from Milan, Italy, "Resistance to nucleoside analogues agents is likely to be multifactorial and could involve a number of mechanisms affecting drug penetration, metabolism and targeting. In vitro studies of resistant human cell lines have confirmed that human concentrative nucleoside transporter 1 (hCNT1)-deficient cells display resistance."

"Experimental design: We applied real-time PCR method to assess them RNA expression of equilibrative and concentrative nucleoside transporter (hENT1, hCNT1), deoxycytidine and deoxyguanosine kinase (dCK, dGK), 5'-nucleotidase (5'-NT), ribonucleotide reductase catalytic and regulatory (RR1, RR2) subunits in bone...

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Source: Blood Weekly (2010-04-22)

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