Large B-Cell Lymphoma
New large B-cell lymphoma findings from Center for Human Genetics published
Published in Blood Weekly, April 22nd, 2010
Data detailed in 'ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions' have been presented. "We report 2 ALK-positive large B-cell lymphoma cases showing granular cytoplasmic and cytoplasmic/nuclear ALK immunostaining in which cryptic ALK rearrangements were identified by fluorescent in situ hybridization and molecular analysis. In the first case, the ALK-involving t(2;3)(p23;q27) masked the cryptic SEC31A-ALK fusion generated by an insertion of the 5' end of SEC31A (4q21) upstream of the 3' end of ALK," investigators in Leuven, Belgium report.
"This rearrangement was associated with loss of the 5' end of ALK and duplication of SEC31A-ALK on...
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Source: Blood Weekly (2010-04-22)
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