Stem Cell Research
Study data from Institute of Technology update knowledge of stem cell research
Published in Blood Weekly, April 29th, 2010
Fresh data on stem cell research are presented in the report 'The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.' "Axotrophin/MARCH-7 was first identified in mouse embryonic stem cells as a neural stem cell gene. Using the axotrophin/MARCH-7 null mouse, we discovered profound effects on T lymphocyte responses, including 8-fold hyperproliferation and 5-fold excess release of the stem cell cytokine leukemia inhibitory factor (LIF)," scientists in Stockholm, Sweden report.
"Our further discovery that axotrophin/MARCH-7 is required for targeted degradation of the LIF receptor subunit gp190 implies a direct role...
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Source: Blood Weekly (2010-04-29)
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