Primary Biliary Cirrhosis

Investigators at University of Alberta target primary biliary cirrhosis

Published in Blood Weekly, May 6th, 2010

"Primary biliary cirrhosis (PBC) reoccurs in a proportion of patients following liver transplantation (LT). The aims of our study were to evaluate the risk factors associated with PBC recurrence and determine whether recurrent disease constitutes a negative predictor for survival," scientists in Edmonton, Canada report.

"One hundred and eight patients receiving LT for end-stage PBC were studied. Recurrent disease was diagnosed in 28 patients (26%). Probability of recurrent PBC at 5 years was 13% and 29% at 10 years with an overall incidence of 3.97 cases per 100 patient years. By univariate Cox analysis use of tacrolimus (HR 6.28, 95% CI, 2.44-16.11, p< 0.001) and...

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Source: Blood Weekly (2010-05-06)

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