Experimental Model

Study data from P.M. Pegofernandes and colleagues update understanding of experimental model

Published in Blood Weekly, May 13th, 2010

According to recent research published in the journal Transplantation Proceedings, "Lung transplantation has become the mainstay therapy for patients with end-stage lung disease refractory to medical management. However, the number of patients listed for lung transplantation largely exceeds available donors."

"The study of lung preservation requires accurate, cost-effective small animal models. We have described a model of ex vivo rat lung perfusion using a commercially available system. Male Wistar rats weighing 250 g-300 g were anesthetized with intraperitoneal sodium thiopental (50 mg/kg body weight). The surgical technique included heart-lung block...

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Source: Blood Weekly (2010-05-13)

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