Breast Cancer

New breast cancer research from University of Pennsylvania discussed

Published in Blood Weekly, May 13th, 2010

New research, 'Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation,' is the subject of a report. According to a study from the United States, "Annexin II, an abundant phospholipids binding cell surface protein, binds tPA and functions as a regulator of fibrinolysis. Annexin II also mediates angiogenesis and enhances tumor growth and metastasis."

"However, the mechanism supporting this role is not known. Using human breast cancer model we show that invasive human breast cancer cells (MDA-MB231) synthesize annexin II and tissue plasminogen activator (tPA). In vitro both annexin II and tPA interacts which in...

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Source: Blood Weekly (2010-05-13)

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