Immunotherapy

Studies from Dalhousie University provide new data on immunotherapy

Published in Blood Weekly, May 20th, 2010

According to recent research from Halifax, Canada, "Using a clinically relevant, fully disparate, allogeneic aortic transplant mouse model of allograft vasculopathy, we have demonstrated that neointimal proliferation is dependent on CD8(+) T cell effector pathways in the presence of therapeutic doses of calcineurin inhibitor (CNI) immunosuppression. CD4(+) T cell pathways are ablated by CNI immunosuppression."

"In the current study, we examined the relationship between CD8(+) T cell activities, medial SMC loss and neointimal hyperplasia. We demonstrate that at 5-6 wk post transplantation in a wild type/wild type transplant CD8(+) T cell infiltration, CD8(+) CTL effector...

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Source: Blood Weekly (2010-05-20)

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