Mononuclear Leukocytes

Studies from Research Center reveal new findings on mononuclear leukocytes

Published in Blood Weekly, May 20th, 2010

"Third-party-specific cytotoxic T lymphocytes (CTL), or veto CTL, are being assessed as a cellular therapeutic for the induction of T-cell tolerance during transplantation. Conceptually, veto cell-expressed antigens (Ags) may induce B-cell immune responses, and this may have deleterious consequences," scientists in the United States report.

"Whether veto cells induce immunity, tolerance, or are ignored by B lymphocytes has, however, not been addressed. CTL were retrovirally transduced with a model cell surface Ag to generate veto CTL. The impact of CTL-specific Ag expression on the activation and tolerization of Ag-specific B cells was assessed in vitro and, using...

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Source: Blood Weekly (2010-05-20)

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