Controlled Release
Data from Ghent University provide new insights into controlled release
Published in Blood Weekly, May 20th, 2010
Scientists discuss in 'Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy' new findings in controlled release. "To exploit the full therapeutic potential of short interfering RNA (siRNA), efficient delivery vehicles are needed as siRNA fails to enter cells spontaneously. Such carriers should also protect siRNA against degradation while it is on its way to the cytosol of the target cells," investigators in Ghent, Belgium report.
"Cationic polymers are widely investigated as siRNA carriers. Cationic polymers and siRNA self-assemble into siRNA polyplexes which have been shown to silence genes in cell cultures. While...
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Source: Blood Weekly (2010-05-20)
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