Clinical Transplantation

Studies from University of Heidelberg yield new information about clinical transplantation

Published in Blood Weekly, May 20th, 2010

According to a study from Heidelberg, Germany, "Recently, we reported that patients with long-term stable good graft function had higher interferon-gamma (IFN-gamma) and lower IL-4 plasma levels late as compared with early post-transplant. These patients had more often detectable CD3+CD4+CD25+IFN-gamma+Foxp3+ peripheral blood lymphocytes (PBL) late post-transplant than patients with impaired graft function."

"We therefore speculated that high plasma IFN-gamma late post-transplant might contribute to the maintenance of graft acceptance. Using ELISA and four-color flow cytometry, plasma cytokines and PBL subpopulations were measured in 65 renal transplant recipients with...

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Source: Blood Weekly (2010-05-20)

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