Eicosanoids
Research data from K. Schror and colleagues update understanding of eicosanoids
Published in Blood Weekly, May 27th, 2010
Data detailed in 'Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins' have been presented. According to a study from Dusseldorf, Germany, "The vast majority of thrombin (>95%) is generated after clotting is completed, suggesting that thrombin formation serves purposes beyond coagulation, such as tissue repair after vessel injury. Two types of vascular thrombin binding sites exist: protease-activated receptors (PARs) and thrombomodulin ™."
"Their expression is low in contractile vascular smooth muscle cells (SMC), the dominating subendothelial cell population, but becomes markedly up-regulated upon injury....
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Source: Blood Weekly (2010-05-27)
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