Initiator Caspases

New findings from University of Tokyo, Medical Department describe advances in initiator caspases

Published in Blood Weekly, May 27th, 2010

According to recent research published in the journal Biochemical and Biophysical Research Communications, "We examined whether and how pretreatment with carbon monoxide (CO) prevents apoptosis of cardioblastic H9c2 cells in ischemia-reperfusion. Reperfusion (6 h) following brief ischemia (10 min) induced cytochrome c release, activation of caspase-9 and caspase-3, and apoptotic nuclear condensation."

"Brief CO pretreatment (10 min) or a caspase-9 inhibitor (Z-LEHD-FMK) attenuated these apoptotic changes. Ischemia-reperfusion increased phosphorylation of Akt at Ser472/473/474, and this was enhanced by CO pretreatment. A specific Akt inhibitor (API-2) blunted the...

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Source: Blood Weekly (2010-05-27)

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