Dengue Virus

Research reports from University of Buenos Aires provide new insights into dengue virus

Published in Blood Weekly, June 10th, 2010

According to recent research from Buenos Aires, Argentina, "Dengue virus envelope glycoprotein (E-protein) is the main protein associated with immunity induction. To produce a candidate for subunit vaccines and to provide an antigen for diagnostic kits, it was expressed in a novel plant system using deconstructed viral modules."

"A truncated version of the E-protein was designed to be expressed alone and co-expressed with Dengue virus structural proteins. As well, the critical domain III of E-protein was fused to hepatitis B core antigen (HBcore). The recombinant proteins were produced in Nicotiana benthamiana plants and were reactive with the anti-E antibody," wrote...

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Source: Blood Weekly (2010-06-10)

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