Drug Development
Researchers from Charite University, Department of Nephrology report details of new studies and findings in the area of drug development
Published in Blood Weekly, June 17th, 2010
New research, 'Target enzyme activity as a biomarker for immunosuppression,' is the subject of a report. According to a study from Berlin, Germany, "Pharmacokinetic drug monitoring has been used for many years to relate immunosuppressant dose to drug exposure in vivo. However, this conventional therapeutic drug monitoring of blood immunosuppressant levels may not necessarily predict the pharmacologic effects on immune cells."
"The direct determination of target enzyme activity (eg, calcineurin activity, inosine-5'-monophospahte dehydrogenase [IMPDH] activity, p70S6 kinase) may help to better assess the individual response to the immunosuppressant. However, its use is...
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Source: Blood Weekly (2010-06-17)
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