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Neuroscience

New neuroscience research from University of Texas, Medical Department outlined

Published in Blood Weekly, June 17th, 2010

According to a study from the United States, "Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia."

"Sprague-Dawley rats were subjected to raised intraocular pressure for 45 min and received intravitreal injections of the specific necroptosis inhibitor, Nec-1, its inactive analogue (Nec-1i) or vehicle. Seven days after ischemia, ERGs were performed and then the eyes were enucleated for histological analysis. In other animals, retinas were subjected to propodium iodide, TUNEL staining or Western Blotting and probed with...

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