Blood Research
Researchers from University of Pittsburgh, Starzl Transplantation Institute describe findings in blood research
Published in Blood Weekly, November 25th, 2010
Data detailed in 'Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation' have been presented. "The prevailing idea regarding the mechanism(s) by which therapeutic immunosuppressive dendritic cells (DCs) restrain alloimmunity is based on the concept that they interact directly with antidonor T cells, inducing anergy, deletion, and/or regulation. However, this idea has not been tested in vivo," researchers in the United States report.
"Using prototypic in vitro-generated maturation-resistant (MR) DCs, we demonstrate that once MR-DCs carrying donor antigen (Ag) are administered...
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Source: Blood Weekly (2010-11-25)
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