DNA Research
Reports Summarize DNA Research Study Results from University of Ulm, Department of Internal Medicine III
Published in Blood Weekly, March 24th, 2011
2011 MAR 24 -- Fresh data on DNA Research are presented in the report 'DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing.' "The DNA damage pathway plays a central role in chemoresistance in chronic lymphocytic leukemia (CLL), as indicated by the prognostic impact of TP53 and ATM loss/mutations. We investigated the function of the p53 axis in primary CLL samples by studying p53 and p21 responses to irradiation by FACS and RT-PCR," investigators in Ulm, Germany report.
"We observed a distinct response pattern for most cases with a 17p deletion (n=16) or a sole TP53 mutation (n=8), but not all...
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Source: Blood Weekly (2011-03-24)
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