Central Nervous System Diseases
New Central Nervous System Diseases Research Has Been Reported by Scientists at Charite University Hospital and School of Medicine
Published in Blood Weekly, April 21st, 2011
2011 APR 21 -- "The aim of this study was to examine the penetration of ifosfamide (IFO) and 4-hydroxy-ifosfamide (4-OH-IFO) into the CSF of human adults and to evaluate the influence of blood-CSF barrier (BCB) function. In 12 adult patients with a malignant CNS disease treated with IFO 1,300-2,000 mg/m(2)/d as a 3-hour intravenous infusion, 17 CSF samples were collected within 10 min after the end of IFO infusion," scientists writing in the journal Cancer Chemotherapy and Pharmacology report.
"In 8 of these patients, the CSF was obtained in up to 5 sequential 2-ml portions to detect a potential caudocranial concentration gradient. Additionally,...
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Source: Blood Weekly (2011-04-21)
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