Myelodysplastic Syndrome

Scientists at Sapienza University of Rome Publish New Data on Myelodysplastic Syndrome

Published in Blood Weekly, May 5th, 2011

2011 MAY 5 -- According to recent research from Rome, Italy, "NF-kB is reported to be constitutively activated in a percentage of high-risk myelodysplastic syndrome carrying cytogenetic aberrations. Only few data are reported on the use of proteasome inhibitors in this subset of patients."

"We performed a study on efficacy and safety of bortezomib as a single agent in patients with myelodysplastic syndromes (MDS). Bortezomib was administered at 1.3mg/m(2) with a 1, 4, 8, 11-day schedule every 28 days, in 19 patients with IPSS low/intermediate 1 or intermediate2/high risk. Six out of 19 patients received all planned eight cycles. Hematologic toxicity was...

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Source: Blood Weekly (2011-05-05)

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