Immunoglobulins

Studies from Fred Hutchinson Cancer Research Center Provide New Data on Immunoglobulins

Published in Blood Weekly, June 2nd, 2011

2011 JUN 2 -- According to a study from Seattle, United States, "It has been presumed that antibody-mediated selective costimulatory molecule blockade of CD28 is superior to cytotoxic T lymphocyte antigen 4 (CTLA4)-Ig. This is based on the premise that specifically blocking CD28 allows inhibitory signals through CTLA-4 to proceed, which furthermore suppresses T-cell function."

"The extracelluar domain of canine (ca)CD28 was cloned from dog peripheral blood mononuclear cells. Mice were immunized with a caCD28/murine IgG2a fusion protein. Hybridomas were produced by fusing splenocytes with mouse NSO cells and screened for caCD28 binding by ELISA. Agonistic...

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Source: Blood Weekly (2011-06-02)

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