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Hemophilia A

Study Results from M. Trossaert and Colleagues in the Area of Hemophilia A Published

Published in Blood Weekly, June 2nd, 2011

2011 JUN 2 -- According to a study from Nantes, France, "In most laboratories, the severity of hemophilia A is assessed by the factor VIII activity (FVIII:C) one-stage assay. However, comparisons of these results with those of two-stage assays can reveal discrepancies and suggest misdiagnosis."

"In this monocentric study, we measured FVIII:C with two methods (one-stage chronometric and chromogenic assays) in 307 (173 families) patients with moderate/mild hemophilia A. To compare results, we used a chronometric/chromogenic ratio. Discrepancy was defined as a ratio < 0.5 or > 1.5. We studied their putative involvement at known FVIII functional sites,...

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