Gases

Reports from S. Drose and Co-Researchers Add New Data to Research in Gases

Published in Blood Weekly, June 16th, 2011

2011 JUN 16 -- "In this study, we have analyzed the effect of different cardioprotective complex II inhibitors on the mitochondrial production of reactive oxygen species (ROS) because ROS seem to be essential for signaling during preconditioning to prevent ischemia/reperfusion injury," researchers in Frankfurt, Germany report.

"Despite different binding sites and concentrations required for half-maximal inhibition-ranging from nanomolar for the Q site inhibitor atpenin A5 to millimolar for the succinate analog malonate-all inhibitors modulated ROS production in the same ambivalent fashion: they promoted the generation of superoxide at the Q(o) site of...

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Source: Blood Weekly (2011-06-16)

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