Cord Blood

Reports Summarize Cord Blood Study Results from Hokkaido University

Published in Blood Weekly, August 18th, 2011

2011 AUG 18 -- According to the authors of a study from Hokkaido, Japan, "Rapamycin has important roles in the modulation of regulatory T cells. We tried to expand CD4 (+) CD25 (+) regulatory T cells (Treg cells) from umbilical cord blood (CB) CD4-positive cells using interleukin (IL)-15 or IL-2 with transforming growth factor (TGF)-beta and rapamycin."

"We were able to obtain more than 500-fold expansion of CD4(+)CD25(+) cells from CB CD4(+) cells using IL-15 and TGF-beta with rapamycin. These expanded CD4(+)CD25(+) cells expressed forkhead box P3 (FoxP3) mRNA at a level about 100-fold higher and could suppress allogeneic mixed lymphocyte culture (MLC) by...

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Source: Blood Weekly (2011-08-18)

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