Published in Blood Weekly, September 1st, 2011
"Here, we identify that CaMKI alpha mediates the M phi response to LPS in vitro and the inflammation and organ dysfunction of sepsis in vivo. We show that LPS induced active pThr(177)-CaMKI alpha in RAW 264.7 cells and murine peritoneal M phi, which if inhibited biochemically with STO609 (CaMKK inhibitor) or by RNAi, reduces LPS-induced...
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