Sepsis

Data on Sepsis Reported by Researchers at University of Pittsburgh

Published in Blood Weekly, September 1st, 2011

2011 SEP 1 -- "Dysregulated Ca2+ handling is prevalent during sepsis and postulated to perpetuate the aberrant inflammation underlying subsequent organ dysfunction and death. The signal transduction cascades mediating these processes are unknown," scientists writing in the Journal of Leukocyte Biology report.

"Here, we identify that CaMKI alpha mediates the M phi response to LPS in vitro and the inflammation and organ dysfunction of sepsis in vivo. We show that LPS induced active pThr(177)-CaMKI alpha in RAW 264.7 cells and murine peritoneal M phi, which if inhibited biochemically with STO609 (CaMKK inhibitor) or by RNAi, reduces LPS-induced...

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Source: Blood Weekly (2011-09-01)

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