Ischemia

Researchers from University Hospital Publish Findings in Ischemia

Published in Blood Weekly, September 15th, 2011

2011 SEP 15 -- "Gap junction intercellular communication (GJIC) and hemichannel permeability may have important roles during an ischemic insult. Our aim was to evaluate the effect of ischemia on gap junction channels and hemichannels," researchers in Tromso, Norway report.

"We used neonatal rat heart myofibroblasts and simulated ischemia with a HEPES buffer with high potassium, low pH, absence of glucose, and oxygen tension was reduced by dithionite. Microinjection, western blot, immunofluorescence, cell viability and dye uptake were used to evaluate the effects induced by dithionite. Isolated perfused rat hearts were used to analyse infarct size. Short...

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Source: Blood Weekly (2011-09-15)

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