Sepsis

New Sepsis Study Findings Recently Were Reported by Y. Zhang and Co-Researchers

Published in Blood Weekly, October 13th, 2011

2011 OCT 13 -- According to the authors of a study from Chongqing, People's Republic of China, "Sepsis is characterized by uncontrolled inflammatory responses. Macrophage migration inhibitory factor (MIF) has been shown to play an important role in the progression of sepsis thus is a potential therapeutic target."

"The aim of this study is to produce IgG anti-MIF monoclonal antibodies (mAbs) with anti-septic abilities in vivo and to determine mechanisms of their function. We generated 8 IgG anti-MIF mAbs with high specificity and 3 of them showed potent protective abilities in murine lethal peritonitis induced by cecal ligation and puncture (CLP). One...

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Source: Blood Weekly (2011-10-13)

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