Ischemia

Study Findings on Ischemia Are Outlined in Reports from J.F. Pedregosa and Colleagues

Published in Blood Weekly, October 13th, 2011

2011 OCT 13 -- "Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs)," researchers in Sao Paulo, Brazil report.

"Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracellular events culminating with the increase in the gene expression of inflammatory cytokines. FTY720 is an immunomodulatory compound and protects at least in part kidneys submitted to IR. The mechanisms associated with FTY720's beneficial effects on kidneys after IR remain elusive. We...

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Source: Blood Weekly (2011-10-13)

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