Serine Endopeptidases
Findings from Vanderbilt University Advance Knowledge in Serine Endopeptidases
Published in Blood Weekly, October 20th, 2011
2011 OCT 20 -- New investigation results, "Activation of factor XI by products of prothrombin activation," are detailed in a study published in Blood. According to the authors of recent research from Nashville, Tennessee, "The prothrombinase complex converts prothrombin to a-thrombin through the intermediate meizothrombin (Mz-IIa). Both a-thrombin and Mz-IIa catalyze factor (F) XI activation to FXIa, which sustains a-thrombin production through activation of FIX."
"The interaction with FXI is thought to involve thrombin anion binding exosite (ABE) I. a-Thrombin can undergo additional proteolysis to ß-thrombin and '-thrombin, neither of which...
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Source: Blood Weekly (2011-10-20)
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