Choline

New Choline Research Reported from University of Delaware

Published in Blood Weekly, October 27th, 2011

2011 OCT 27 -- "Platelet-activating factor acetylhydrolase type II (PAFAH-II) is an intracellular phospholipase A(2) enzyme that hydrolyzes platelet-activating factor and oxidatively fragmented phospholipids. This N-terminally myristoylated protein becomes associated with cytoplasm-facing cell membranes under oxidative stress," researchers in Newark, Delaware report.

"The structural requirements for binding of PAFAH-II to membranes in response to oxidative stress are unknown. To begin elucidating the mechanism of trafficking and stress response, we constructed a homology model of PAFAH-II. From the predicted membrane orientation of PAFAH-II, the N-terminal...

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Source: Blood Weekly (2011-10-27)

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