Endogenous Retroviruses

Study Findings from J. Lee et al Provide New Insights into Endogenous Retroviruses

Published in Blood Weekly, October 27th, 2011

2011 OCT 27 -- According to the authors of recent research from Chungbuk, South Korea, "In cases of retroviral infection, the host cell deploys antiviral proteins as a type of innate immunity. Tripartite motif-containing 5-isoform alpha (TRIM5 alpha) is a potent antiviral protein."

"TRIM5 alpha has been reported to restrict human immunodeficiency virus (HIV) 1 infection in rhesus monkey cells by targeting the incoming viral capsid at the postentry or preintegration stage of the viral life cycle. As a consequence, virus replication and reverse transcription are interrupted. TRIM5 alpha of human origin has also been shown to inhibit N-tropic murine leukemia...

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Source: Blood Weekly (2011-10-27)

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