Stem Cell Research

Findings from Akita University Advance Knowledge in Stem Cell Research

Published in Blood Weekly, October 27th, 2011

2011 OCT 27 -- According to the authors of recent research from Akita, Japan, "Itraconazole is a potent inhibitor of CYP3A4 and P-glycoprotein, but not CYP2C9. Herein, we report a case study in which the plasma concentration of the CYP2C9 substrate (S)-warfarin, and not the CYP3A4 substrate ®-warfarin, increased with itraconazole coadministration."

"A 67-y-old man received an allogenic bone marrow transplant for acute lymphoid leukemia. He was taking oral itraconazole (200 mg/day) and was started on a warfarin dose of 2.0 mg/day. The plasma concentrations of (S)- and ®-warfarin 3 days after starting warfarin administration were 216 and 556 ng/mL,...

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Source: Blood Weekly (2011-10-27)

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