Scientists at National Academy of Sciences Describe Research in Ischemia

2011 NOV 17 -- According to the authors of a study from Kharkov, Ukraine, "The ability of the mitochondria-targeted plastoquinone derivative 10-(6'-plastoquinonyl) decyl triphenylphosphonium (SkQ1) to decrease ischemia-reperfusion injury in isolated liver during hypothermic storage (HS) was studied. Rat liver was stored for 24 h at 4 C without or in the presence of 1 mc M SkQ1 with following reperfusion for 60 min at 37 degrees C. The presence in the storage medium of SkQ1 significantly decreased spontaneous production of reactive oxygen species and intensity of lipid peroxidation in the liver during HS and reperfusion."

"The GSH level after HS in solution...

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