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Blood Transfusion

Studies Conducted at Johns Hopkins University on Blood Transfusion Recently Published

Published in Blood Weekly, December 8th, 2011

2011 DEC 8 -- "The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients," scientists in Baltimore, Maryland report.

"We identified 37 consecutive apheresis PLT recipients who experienced an ATR and 26 matched controls. Total immunoglobulin (Ig)E and aero- and food allergen-specific IgE were quantified in plasma by a blood test for allergies (ImmunoCAP: Phadiatop and Fx5). IgE testing of apheresis PLT supernatants was also performed. Pruritus and urticaria were manifest in 91.9 and 83.8% of all...

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