Iron-Binding Proteins
Research from Chinese Academy of Sciences Provide New Insights into Iron-Binding Proteins
Published in Blood Weekly, December 15th, 2011
2011 DEC 15 -- "The hypomethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) and its derivatives have been successfully used for the treatment of myelodysplastic syndromes, and they frequently improve the anemia that usually accompanies these disorders. However, the molecular mechanisms underlying this action remain poorly understood," scientists in Beijing, People's Republic of China report.
"In this study, we used two erythroid models, murine erythroid leukemia cells and erythroid burst-forming unit-derived erythroblasts, to show that 5-aza-CdR induced erythroid differentiation and increased the expression of transferrin receptor 1 (TfR1) and...
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Source: Blood Weekly (2011-12-15)
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