Inflammation

Findings from Necker Hospital for Sick Children in Inflammation Reported

Published in Blood Weekly, December 15th, 2011

2011 DEC 15 -- "Purpose of review The inhibition of mTOR promotes immune tolerance in mouse models of transplantation, by favoring the expansion of regulatory T cells over effector T cells. However, attempts at inducing immune tolerance with the mTOR inhibitor (mTOR-I) in humans have so far failed," investigators in Paris, France report.

"We herein review the immunological obstacles that need to be overcome in order to translate mTOR-I-related tolerogenic properties into the clinic. Recent findings Our knowledge of regulatory T-cell biology has exploded over the past few years, providing clues to explain the complex impact of prolonged mTOR inhibition on...

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Source: Blood Weekly (2011-12-15)

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