Sepsis
Recent Findings in Sepsis Described by Researchers from Osaka University
Published in Blood Weekly, December 29th, 2011
2011 DEC 29 -- Investigators publish new data in the report "The decreases of nephrin and nuclear WT1 in podocytes may cause albuminuria during the experimental sepsis in mice. 'Sepsis is induced by infectious challenges, and septic organ failure often occurs under local and systemic inflammation. Albuminuria is also evident during sepsis, but little is known about the molecular basis of septic albuminuria," scientists in Osaka, Japan report.
"Using lipopolysaccharide (LPS)-treated mice as a sepsis model, we found that the loss of nephrin, a key component for maintaining podocyte slit diaphragm, became evident in accordance with the onset of albuminuria,...
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Source: Blood Weekly (2011-12-29)
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